River Runs Red follows respected Judge Charles Coleman (Taye Diggs), who has devoted his life to law enforcement. When his son is shot in a traffic stop gone awry, Coleman turns to his long-time friend, Detective Horace (John Cusack), and discovers an unchecked pattern of violence with these same cops. Betrayed by the system he swore to uphold, Coleman joins forces with another bereaved father (George Lopez), and the two men take the law into their own hands.