In the movie What If, starring Daniel Radcliffe, of Harry Potter fame, medical school dropout Wallace (Daniel Radcliffe) has been repeatedly burned by bad relationships. He meets Chantry (Zoe Kazan), an animator who lives with her longtime boyfriend Ben (Rafe Spall), and they form an instant connection, striking up a close friendship. Still, there is no denying the chemistry between them, leading the pair to wonder, what if the love of your life is actually your best friend?